A healing bump is a raised bump that typically just grows right above the piercing site. Keloids are very firm scars that are usually pink to red in color. These clusters of excess scar tissue raise up above the skin and tend to grow larger and cover more surface area over time. Keloid scars can be extremely itchy, tender when you place any sort of pressure on them and can be painful at times too. Dermatologist Ellen Marmur, MD, explains that it’s an area of irregular fibrous tissue that usually forms at the site of a scar or injury, which includes piercings.
Special techniques must be used soon after the surgical procedure has concluded to prevent the formation of a new, larger keloid. The fact that keloids tend to spread out and cover a larger area than the injury or wound itself is one of the easiest ways to tell the difference between the common healing bump and a keloid.
Vascular endothelial growth factors VEGF plays a significant role in neovascularization and have been linked to keloids disease. Platelet Derived Growth Factor and Connective Tissue Growth Factor are other growth factors that play an important role in the proliferative phase. These factors have been implicated in keloid formation . Keloid scars are an overgrowth of skin after a cut or injury. They can also occur after surgery, done by doctors – for example, after ear reduction surgery or for removal of a suspicious skin growth.
But your cute new nose or lobe piercing doesn’t have to be plagued by the bump forever. With the help of a medical professional, you can have it safely removed. Another possible reaction is keloids, which are raised scars that grow past the bounds of the original injury, according to the American Academy of Dermatology .
Neoangiogenesis increases the recruitment of cells, such as macrophages and fibroblasts, to the wound site. Active neovascularization has been implicated in keloid disease.
This maybe indicates that very few people have a high predisposition to develop keloids, but this finding needs more research . Several factors play a significant role in keloids formation . The genetic predisposition is the most important factor; other factors are blood groups, melanin, the anatomical site, the type of skin injury, the age of onset, and sex . Transforming growth factor beta (TGF-b) plays a central role in wound healing and fibrosis and has been implicated in the pathogenesis of keloid.
Keloid fibroblasts have been shown to make elevated levels of TGF-b, a growth factor known to stimulate growth and collagen secretion and are thought to be integral to keloid formation [12-14]. Neovascularization is the process of new blood vessel formation in response to tissue malnutrition. New vessels are formed from solid endothelial sprouts that migrate from the wound edges to the central area. Chemical mediators like bradykinin and prostaglandin, from macrophages induce migration and mitosis of endothelial cells.
However, it is a limited option because it is toxic to healthy tissue. Compression treatments include button compression, pressure earrings , ACE bandages, elastic adhesive bandages, compression wraps, spandex or elastane bandages, and support bandages. In one study, button compression prevented recurrence during 8 months to 4 years of follow-up observation . A previous study reported that 1.93% of patients have keloids caused by two different causes, and distributed on multiple anatomical sites.