It’s also possible for keloids to form on uninjured skin. These keloids are called “spontaneous keloids.” They usually appear on the chest and develop in people who have a family history of developing keloids. When keloids develop spontaneously, it’s more likely that several keloids will appear. Some women who have had a cesarean section (C-section) or hysterectomy get keloids after the surgery. Young adults who have dark skin are more likely to develop a keloid.
Most appear within a year of whatever caused the skin to scar. After getting her ears pierced, this raised scar slowly developed.
Those keloid patients who have no other keloid formers in their family are unlikely to pass the keloids on to their children. However, it cannot be excluded that their offspring have an increased risk to develop keloids. Most likely several minor mutations in the genome are necessary to cause those keloids. We believe that in the US only about 1 % of keloid cases are inherited.
A large or irritating keloid may be removed with surgery. This may be limited as an option because it is toxic to healthy tissue.
Certain factors predispose you to keloids, like being a person of color and having a family history of these scars, the AAD explains. Lilfesil of Brazil unveiled a new type of breast implant as a option to silicone, along with gel sheets to minimize scars and keloids.
Although keloids can develop earlier or later, children and the elderly rarely get a keloid when they scar. After keloid surgery, keeping pressure on the area reduces blood flow. People who are more likely to get keloids may decide not to get a body piercing or tattoo. If you get your ears pierced, you should wear special pressure earrings to reduce scarring on your earlobes.
We perform basic research to understand the cause for keloids. Based on this knowledge we expect that better treatment can be developed in the future.
In the hereditary form of keloids it is possible that there is one major gene mutation that puts family members at risk for developing keloids. There may be other variations in the DNA that determine whether keloids become large and aggressive or stay small and without many symptoms. It is unknown whether the environment have an effect on keloids.
In one study, 13 keloids were treated with excision in combination with nightly applications of imiquimod 5% cream for 8 weeks. Ten patients with 11 keloids completed the 6-month study, and no keloids recurred after 6 months. Mild irritation was experienced with the application of imiquimod, and some patients needed a vacation period from the medication . Verapamil is a calcium channel blocker that blocks the synthesis and secretion of extracellular matrix molecules and increases fibrinase. A previous study reported complete resolution of 4 of 6 keloids at 1-year follow-up after surgical removal of the scar and further intralesional injection of verapamil at doses of 2.5 mg/mL .
Keloids can develop after surgery, injuries, ear piercing, vaccinations, acne or minor scratches. Keloids develop after injuries to the skin of most body parts but are rare on the palm of the hand or the sole of the foot. 1-Avoid performing nonessential cosmetic surgery in patients known to form keloids; however, the risk is lower among patients who have only earlobe lesions. Imiquimod, an immunomodulator, increases the production of numerous cytokines; IFN-alpha, IFN-gamma, IL-1, IL-4, IL- 5, IL-6, IL-8, and IL-12 and alters the expression of markers for apoptosis.